Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 7/20 | 0.40 |
| ▸ | PTGES | O14684 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006137 | 0.94 | MAPT (0.42) | MAPTPPARGMEN1KMT2APTGES2 | |
| SCHEMBL2011368 | 0.93 | PTGES2 (0.41) | MAPTPPARGMEN1KMT2APTGES2 | |
| SCHEMBL2006816 | 0.93 | LMNA (0.42) | MAPTMEN1CYP3A4ALOX15ALOX12 | |
| SCHEMBL2006431 | 0.92 | MAPK1 (0.50) | MAPTPPARGMEN1CYP3A4ALOX15 | |
| SCHEMBL2002253 | 0.92 | PLA2G2A (0.46) | MAPTMEN1CYP3A4TSHRKMT2A | |
| SCHEMBL2004532 | 0.91 | PTGES2 (0.42) | MAPTCYP3A4ALOX15TSHRALOX12 | |
| SCHEMBL2004704 | 0.90 | LMNA (0.38) | MAPTPPARGCYP3A4TSHRALOX12 | |
| SCHEMBL2004616 | 0.89 | ALOX5AP (0.42) | MAPTMEN1CYP3A4TSHRKMT2A | |
| SCHEMBL2004657 | 0.88 | FAAH (0.38) | MAPTPPARGMEN1CYP3A4ALOX15 | |
| SCHEMBL2003580 | 0.88 | MAPT (0.44) | MAPTPPARGMEN1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |