Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.66 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.65 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.61 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.61 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.61 |
| ▸ | PTGES | O14684 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004647 | 0.90 | AKR1C3 (0.64) | CNR2AKR1C3AKR1C2LMNACYP1A2 | |
| SCHEMBL2005522 | 0.89 | AKR1C3 (0.63) | CNR2AKR1C3AKR1C2LMNACYP1A2 | |
| SCHEMBL2005253 | 0.85 | PTGS1 (0.58) | CNR2AKR1C3AKR1C2LMNACYP1A2 | |
| SCHEMBL10876035 | 0.82 | AKR1C3 (0.76) | AKR1C3AKR1C2LMNACYP1A2CYP2C9 | |
| SCHEMBL2008730 | 0.81 | AKR1C3 (0.64) | AKR1C3AKR1C2LMNACYP1A2CYP2C9 | |
| SCHEMBL2004091 | 0.81 | PTGS1 (0.48) | CNR2AKR1C3AKR1C2LMNACYP1A2 | |
| SCHEMBL2008278 | 0.81 | PTGS1 (0.63) | CNR2AKR1C3AKR1C2LMNACYP1A2 | |
| SCHEMBL2002180 | 0.80 | AKR1C3 (0.65) | AKR1C3AKR1C2LMNACYP1A2CYP2C9 | |
| SCHEMBL2010113 | 0.80 | AKR1C3 (0.65) | AKR1C3AKR1C2LMNACYP1A2CYP2C9 | |
| SCHEMBL2073076 | 0.80 | AKR1C3 (0.68) | AKR1C3AKR1C2LMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628532-A2 | METHODS FOR THE PROTECTION OF MEMORY AND COGNITION | Microbia, Inc. (US) | 2006-03-01 | — | — | EP | claimed |
| US-20050004104-A1 | Methods for the protection of memory and cognition | IRONWOOD PHARMACEUTICALS, INC. | 2005-01-06 | — | — | US | claimed |
| WO-2004108085-A2 | METHODS FOR THE PROTECTION OF MEMORY AND COGNITION | MICROBIA, INC. (US) | 2004-12-16 | — | — | WO | claimed |
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-20070203209-A1 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. | 2007-08-30 | — | — | US | disclosed |
| EP-1628532-A2 | METHODS FOR THE PROTECTION OF MEMORY AND COGNITION | Microbia, Inc. (US) | 2006-03-01 | — | — | EP | disclosed |
| US-20050234030-A1 | Modulators of CRTH2, COX-2 and FAAH | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
| US-20050004104-A1 | Methods for the protection of memory and cognition | IRONWOOD PHARMACEUTICALS, INC. | 2005-01-06 | — | — | US | disclosed |
| WO-2004108085-A2 | METHODS FOR THE PROTECTION OF MEMORY AND COGNITION | MICROBIA, INC. (US) | 2004-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004104-A1 | Methods for the protection of memory and cognition | PTGES2, PTGS2, PTGS1 | CNR2 393/4885AKR1C3 2613/4885AKR1C2 1928/4885 |
| US-20100197708-A1 | INDOLE COMPOUNDS | IDO1, IDO2, TPH2 | CNR2 20/4885AKR1C3 1274/4885AKR1C2 1417/4885 |
| US-20070203209-A1 | Useful indole compounds | TPH2, HRH2, HRH1 | CNR2 11/4885AKR1C3 1451/4885AKR1C2 1219/4885 |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | CNR2 28/4885AKR1C3 970/4885AKR1C2 848/4885 |
| US-20050234030-A1 | Modulators of CRTH2, COX-2 and FAAH | FAAH2, FAAH, PTGES2 | CNR2 6/4885AKR1C3 1303/4885AKR1C2 1007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.