Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.39 |
| ▸ | CA1 | P00915 | 15/20 | 0.39 |
| ▸ | CA9 | Q16790 | 14/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 10/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2781799 | 0.85 | TSHR (0.35) | CA2CA1CA12CA14CA7 | |
| SCHEMBL1601701 | 0.84 | ALDH1A1 (0.34) | CA2CA1CA12CA14CA7 | |
| SCHEMBL5004808 | 0.74 | PLA2G10 (0.39) | — | |
| SCHEMBL746094 | 0.74 | CTRB1 (0.35) | — | |
| SCHEMBL5754991 | 0.74 | TAAR1 (0.39) | — | |
| SCHEMBL230546 | 0.73 | CTRB1 (0.36) | — | |
| SCHEMBL133894 | 0.72 | MEN1 (0.36) | — | |
| SCHEMBL6076922 | 0.71 | TSHR (0.40) | — | |
| SCHEMBL388934 | 0.71 | ALDH1A1 (0.36) | — | |
| SCHEMBL3369296 | 0.71 | IDO1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964633-B2 | such as N,N'-[hexane-1,6-diylbis(iminocarbonyl)]bis(3-chlorobenzenesulfonamide), used as Fructose-1,6-bisphosphatase inhibitors; metabolic disorders such as diabetes | HOFFMANN-LA ROCHE INC. (US) | 2011-06-21 | — | — | US | disclosed |
| EP-2081889-B1 | SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-12-22 | — | — | EP | disclosed |
| EP-2081889-A1 | SULFONAMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-07-29 | — | — | EP | disclosed |
| US-20090118323-A1 | ANTITUMOR BENZOYLSULFONAMIDES | MADER MARY MARGARET | 2009-05-07 | — | — | US | disclosed |
| US-20080085928-A1 | Sulfonamide derivatives | HOFFMANN-LA ROCHE INC. | 2008-04-10 | — | — | US | disclosed |
| WO-2008037628-A1 | SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-03 | — | — | WO | disclosed |
| EP-1565438-B1 | ANTITUMOR BENZOYLSULFONAMIDES | LILLY CO ELI (US) | 2007-10-17 | — | — | EP | disclosed |
| US-7282595-B2 | Antitumor benzoylsulfonamides | ELI LILLY AND COMPANY (US) | 2007-10-16 | — | — | US | disclosed |
| US-20060106053-A1 | Antitumor benzoylsulfonamides | ELI LILLY AND COMPANY | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118323-A1 | ANTITUMOR BENZOYLSULFONAMIDES | HCCS, GLS2, GLS | CA2 1594/4885CA1 428/4885CA9 59/4885 |
| US-20060106053-A1 | Antitumor benzoylsulfonamides | HCCS, GLS2, GLS | CA2 1594/4885CA1 428/4885CA9 59/4885 |
| US-20080085928-A1 | Sulfonamide derivatives | SULT2A1, SULT1A1, SULT1E1 | CA2 1137/4885CA1 2532/4885CA9 1183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.