Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10535235 | 0.80 | GABRG2 (0.48) | USP30GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2320835 | 0.78 | FLT1 (0.44) | NPC1RAB9ASMN1; SMN2TET3BBOX1 | |
| SCHEMBL10538628 | 0.74 | NOTUM (0.47) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL22594332 | 0.69 | NPC1 (0.59) | USP30NPC1TP53TSHRNFKB1 | |
| SCHEMBL23604037 | 0.68 | NOTUM (0.41) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL817554 | 0.66 | ALOX5 (0.65) | NPC1TP53TSHRNFKB1RAB9A | |
| SCHEMBL31222672 | 0.66 | ALOX5 (0.65) | NPC1TP53TSHRNFKB1RAB9A | |
| SCHEMBL31040042 | 0.65 | NOTUM (0.46) | NPC1TP53TSHRNFKB1RAB9A | |
| SCHEMBL57437 | 0.64 | ALDH1A1 (0.54) | NPC1TSHRRAB9ASMN1; SMN2IDO1 | |
| SCHEMBL13039531 | 0.64 | ALDH1A1 (0.54) | NPC1TSHRRAB9ASMN1; SMN2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065768-A1 | CYANO-SUBSTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-12 | — | — | WO | disclosed |