Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15538352 | 0.92 | GRM3 (0.40) | GPR119HRH3BCHEACHEHDAC4 | |
| SCHEMBL15538353 | 0.92 | GRM3 (0.40) | GPR119HRH3BCHEACHEHDAC4 | |
| SCHEMBL20053731 | 0.91 | GPR119 (0.41) | GPR119HRH3BCHEACHENR3C1 | |
| SCHEMBL15539714 | 0.89 | ACHE (0.45) | GPR119BCHEACHE | |
| SCHEMBL15538194 | 0.87 | BCHE (0.41) | GPR119BCHEACHE | |
| SCHEMBL20053643 | 0.87 | GPR119 (0.43) | GPR119HRH3BCHEACHENR3C1 | |
| SCHEMBL20053577 | 0.86 | GPR119 (0.45) | GPR119HRH3ADRB2HPGDCYP2D6 | |
| SCHEMBL15538466 | 0.86 | SPHK1 (0.43) | GPR119BCHEACHEALDH1A1L3MBTL1 | |
| SCHEMBL15538168 | 0.86 | SPHK1 (0.43) | GPR119BCHEACHEALDH1A1L3MBTL1 | |
| SCHEMBL20053619 | 0.85 | GPR119 (0.60) | GPR119HRH3KDM4EHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858986-B1 | PIPERIDINE DERIVATIVES AS GPR119 AGONISTS | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2019-10-30 | — | — | EP | disclosed |
| US-9944600-B2 | Piperidine derivatives for GPR119 agonist | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2018-04-17 | — | — | US | disclosed |