Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14297019 | 0.87 | POLB (0.49) | POLBMAPTNPC1MAPK1RAB9A | |
| SCHEMBL14297018 | 0.82 | POLB (0.67) | POLBMAPTNPC1MAPK1RAB9A | |
| SCHEMBL20196333 | 0.82 | POLB (0.45) | POLBMAPTNPC1MAPK1RAB9A | |
| SCHEMBL20054835 | 0.81 | POLB (0.46) | POLBMAPTNPC1MAPK1RAB9A | |
| SCHEMBL20054903 | 0.81 | POLB (0.46) | POLBRXFP1MAPTNPC1MAPK1 | |
| SCHEMBL23615473 | 0.81 | HDAC3 (0.58) | POLBMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19647099 | 0.81 | L3MBTL1 (0.47) | POLBMAPTNPC1MAPK1RAB9A | |
| SCHEMBL13625388 | 0.81 | POLB (0.51) | POLBMAPTNPC1MAPK1RAB9A | |
| SCHEMBL13643864 | 0.79 | POLB (0.47) | POLBMAPTNPC1MAPK1RAB9A | |
| SCHEMBL13471907 | 0.79 | THRA (0.49) | POLBMAPTNPC1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2018-04-18 | — | — | EP | disclosed |