Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14297019 | 0.86 | POLB (0.49) | POLBHPGDALDH1A1TSHRNPC1 | |
| SCHEMBL14297018 | 0.84 | POLB (0.67) | POLBHPGDNPC1MAPTMAPK1 | |
| SCHEMBL20196333 | 0.83 | POLB (0.45) | POLBHPGDALDH1A1TSHRNPC1 | |
| SCHEMBL23615473 | 0.82 | HDAC3 (0.58) | POLBHPGDALDH1A1NPC1MAPT | |
| SCHEMBL19647099 | 0.82 | L3MBTL1 (0.47) | POLBHPGDUSP2ALDH1A1TSHR | |
| SCHEMBL20054903 | 0.82 | POLB (0.46) | POLBALDH1A1TSHRNPC1MAPT | |
| SCHEMBL13625388 | 0.82 | POLB (0.51) | POLBHPGDALDH1A1NPC1MAPT | |
| SCHEMBL20054859 | 0.81 | POLB (0.45) | POLBHPGDUSP2ALDH1A1NPC1 | |
| SCHEMBL13471907 | 0.80 | THRA (0.49) | POLBHPGDUSP2ALDH1A1TSHR | |
| SCHEMBL14297023 | 0.79 | ALDH1A1 (0.57) | POLBHPGDALDH1A1TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2018-04-18 | — | — | EP | disclosed |