Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14297019 | 0.86 | POLB (0.49) | POLBMAPK1NPC1MAPTRAB9A | |
| SCHEMBL14297018 | 0.84 | POLB (0.67) | POLBMAPK1NPC1MAPTRAB9A | |
| SCHEMBL12735068 | 0.84 | NAAA (0.52) | MAPK1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL19647099 | 0.83 | L3MBTL1 (0.47) | POLBMAPK1NPC1MAPTRAB9A | |
| SCHEMBL20054903 | 0.83 | POLB (0.46) | POLBMAPK1NPC1MAPTRAB9A | |
| SCHEMBL23615473 | 0.83 | HDAC3 (0.58) | POLBNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL20054835 | 0.83 | POLB (0.46) | POLBMAPK1NPC1MAPTRAB9A | |
| SCHEMBL13625388 | 0.82 | POLB (0.51) | POLBMAPK1NPC1MAPTRAB9A | |
| SCHEMBL20054859 | 0.82 | POLB (0.45) | POLBMAPK1NPC1MAPTRAB9A | |
| SCHEMBL2722040 | 0.81 | LMNA (0.46) | MAPK1NPC1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327027-A1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | Pfizer Inc (US) | 2018-05-30 | — | — | EP | disclosed |