Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | APP | P05067 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14962758 | 0.86 | ADRB2 (0.54) | PTPRBADRB2LMNAXBP1ACACB | |
| SCHEMBL16015558 | 0.85 | ADRB2 (0.39) | PTPRBADRB2LMNAXBP1ACACB | |
| SCHEMBL14962753 | 0.85 | PTPRB (0.36) | PTPRBADRB2LMNAXBP1ACACB | |
| SCHEMBL17480096 | 0.84 | LMNA (0.36) | PTPRBADRB2LMNAXBP1ACACB | |
| SCHEMBL19647062 | 0.82 | LOXL2 (0.49) | PTPRBADRB2LMNAXBP1ACACB | |
| SCHEMBL14962671 | 0.82 | PDPK1 (0.41) | PTPRBLMNAALOX5SLC6A2SLC6A4 | |
| SCHEMBL20196263 | 0.82 | PDPK1 (0.41) | PTPRBLMNAALOX5SLC6A2SLC6A4 | |
| SCHEMBL14962659 | 0.82 | PDPK1 (0.41) | PTPRBLMNAALOX5SLC6A2SLC6A4 | |
| SCHEMBL21010058 | 0.71 | FBP1 (0.36) | LMNAMAPKAPK2ALOX5SLC6A2SLC6A4 | |
| SCHEMBL12041576 | 0.71 | FBP1 (0.36) | LMNAMAPKAPK2ALOX5SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2018-04-18 | — | — | EP | disclosed |