Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14962671 | 1.00 | PDPK1 (0.41) | PDPK1LMNAPTPRBPKMTRPA1 | |
| SCHEMBL14962659 | 1.00 | PDPK1 (0.41) | PDPK1LMNAPTPRBPKMTRPA1 | |
| SCHEMBL19200381 | 0.88 | LMNA (0.39) | PDPK1LMNAPTPRBPKMTAAR1 | |
| SCHEMBL19647400 | 0.86 | TRPA1 (0.41) | PDPK1LMNAPTPRBPKMTRPA1 | |
| SCHEMBL17480096 | 0.86 | LMNA (0.36) | LMNAPTPRBSLC6A2SLC6A4ALOX5 | |
| SCHEMBL19647062 | 0.84 | LOXL2 (0.49) | LMNAPTPRBTAAR1CYP2A6CTSA | |
| SCHEMBL14968411 | 0.83 | MAOA (0.44) | PDPK1LMNAPTPRBPKMTAAR1 | |
| SCHEMBL14962698 | 0.83 | MAOA (0.44) | PDPK1LMNAPTPRBPKMTAAR1 | |
| SCHEMBL14962758 | 0.82 | ADRB2 (0.54) | LMNAPTPRBSLC6A2SLC6A4CYP2A6 | |
| SCHEMBL20054899 | 0.82 | PTPRB (0.38) | LMNAPTPRBSLC6A2SLC6A4ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3549583-A1 | SYNERGISTIC AURISTATIN COMBINATIONS | Pfizer Inc (US) | 2019-10-09 | — | — | EP | disclosed |
| EP-3327027-A1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | Pfizer Inc (US) | 2018-05-30 | — | — | EP | disclosed |