Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 1/20 | 0.42 |
| ▸ | ADH1C | P00326 | 1/20 | 0.42 |
| ▸ | ADH1A | P07327 | 1/20 | 0.42 |
| ▸ | ADH4 | P08319 | 1/20 | 0.42 |
| ▸ | ADH7 | P40394 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 4/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16557197 | 0.83 | GSR (0.40) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL23615392 | 0.78 | CPB2 (0.36) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL19891917 | 0.78 | GNAI3 (0.51) | DPP7DPP8DPP9GNAI3GNAO1 | |
| SCHEMBL27321591 | 0.76 | TLR2 (0.47) | DPP7DPP8DPP9GNAI3GNAO1 | |
| SCHEMBL17210488 | 0.76 | GSR (0.42) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL19851644 | 0.74 | SIRT1 (0.69) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL1168511 | 0.74 | GSR (0.53) | SLC6A5CA1GSRFOLH1 | |
| SCHEMBL18105654 | 0.74 | GSR (0.44) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL1168516 | 0.74 | GSR (0.53) | SLC6A5CA1GSRFOLH1 | |
| SCHEMBL13218612 | 0.74 | GSR (0.44) | ADH1BADH1CADH1AADH4ADH7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2018-04-18 | — | — | EP | disclosed |