Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15507102 | 0.81 | GPR119 (0.53) | ALDH1A1SMN1; SMN2GPR119FAAHMEN1 | |
| SCHEMBL29205308 | 0.77 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4ECYP2A6PTGS2 | |
| SCHEMBL28760303 | 0.76 | MAPK9 (0.47) | ALDH1A1SMN1; SMN2GPR119FAAH | |
| SCHEMBL23884857 | 0.74 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2AKDM4ECYP2A6 | |
| SCHEMBL11442828 | 0.73 | KDM4E (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL27662257 | 0.72 | L3MBTL1 (0.47) | ALDH1A1SMN1; SMN2GPR119FAAHLMNA | |
| SCHEMBL2568999 | 0.68 | FGFR1 (0.72) | ALDH1A1KDM4EHTTFGFR1 | |
| SCHEMBL29512158 | 0.68 | FGFR1 (0.72) | ALDH1A1KDM4EHTTFGFR1 | |
| SCHEMBL24311359 | 0.68 | HTT (0.49) | ALDH1A1SMN1; SMN2MITFLMNAHTT | |
| SCHEMBL24528609 | 0.68 | XDH (0.44) | ALDH1A1GRM1PTGS2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892888-B1 | N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2018-04-18 | — | — | EP | disclosed |