Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | LPL | P06858 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12452414 | 0.93 | PLK1 (0.50) | PLK1LPLLIPGCA2ALDH1A1 | |
| SCHEMBL19829477 | 0.86 | RARB (0.54) | LPLLIPGHRH3MAPTALDH1A1 | |
| SCHEMBL9418558 | 0.84 | LPL (0.43) | PLK1MCL1LPLLIPGNISCH | |
| SCHEMBL4802707 | 0.83 | LPL (0.54) | PLK1MCL1LPLLIPGNISCH | |
| SCHEMBL18664826 | 0.82 | UCHL1 (0.53) | PLK1KIF11NPC1MAPTRAB9A | |
| SCHEMBL2098522 | 0.80 | PLK1 (0.53) | PLK1NPC1RAB9ACA2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28291713 | 0.79 | CA2 (0.41) | PLK1MCL1LPLLIPGNISCH | |
| SCHEMBL22951099 | 0.78 | HRH3 (0.47) | PLK1MCL1LPLLIPGNISCH | |
| Hydrochloric Acid SCHEMBL2863755 | 0.78 | PLK1 (0.52) | PLK1NPC1RAB9ACA2ALDH1A1 | |
| SCHEMBL27496644 | 0.78 | ESR1 (0.55) | LPLLIPGCA2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3309150-A1 | BIPHENYL-ETHYL-PYRROLIDINE DERIVATIVES AS HISTAMINE H3 RECEPTOR MODULATORS FOR THE TREATMENT OF COGNITIVE DISORDERS | Arena Pharmaceuticals, Inc. (US) | 2018-04-18 | — | — | EP | disclosed |