Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 7/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.72 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.72 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.72 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.72 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | PTGES | O14684 | 1/20 | 0.72 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5435359 | 0.94 | PTGS1 (0.88) | PTGS2PTGS1AKR1C3AKR1C2ABCB1 | |
| SCHEMBL5447423 | 0.93 | PTGS1 (0.86) | PTGS2PTGS1AKR1C3AKR1C2ABCB1 | |
| SCHEMBL5444132 | 0.93 | PTGS2 (0.86) | PTGS2PTGS1AKR1C3AKR1C2ABCB1 | |
| SCHEMBL2461597 | 0.92 | PTGS2 (0.86) | PTGS2PTGS1AKR1C3AKR1C2ABCB1 | |
| SCHEMBL5444258 | 0.92 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3AKR1C2ABCB1 | |
| SCHEMBL3004026 | 0.92 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3AKR1C2ABCB1 | |
| SCHEMBL5560525 | 0.90 | PTGS2 (0.82) | PTGS2PTGS1AKR1C3AKR1C2ABCB1 | |
| SCHEMBL2005792 | 0.90 | PTGS1 (0.82) | PTGS2PTGS1AKR1C3AKR1C2ABCB1 | |
| SCHEMBL2007174 | 0.90 | PTGS1 (0.81) | PTGS2PTGS1AKR1C3AKR1C2ABCB1 | |
| SCHEMBL2001089 | 0.89 | PTGS1 (0.81) | PTGS2PTGS1AKR1C3AKR1C2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006099416-A1 | 2-METHYL INDOLE CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2006-09-21 | — | — | WO | claimed |
| US-8481587-B2 | Substituted 2-(5-hydroxy-2-methyl-1H-indole-3-yl)acetic acids and ethers thereof and the use of same to treat viral diseases | IVASHCHENKO ANDREY ALEXANDROVICH (RU) | 2013-07-09 | — | — | US | disclosed |
| US-8481587-B2 | Substituted 2-(5-hydroxy-2-methyl-1H-indole-3-yl)acetic acids and ethers thereof and the use of same to treat viral diseases | IVASHCHENKO ANDREY ALEXANDROVICH (RU) | 2013-07-09 | — | — | US | disclosed |
| US-20110230524-A1 | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOLE-3-YL)ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES | ALLA CHEM, LLC. | 2011-09-22 | — | — | US | disclosed |
| US-20110230524-A1 | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOLE-3-YL)ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES | ALLA CHEM, LLC. | 2011-09-22 | — | — | US | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| WO-2010062221-A1 | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1N-INDOLE-3-IL) ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES | АЛЛА XEM, ЛЛС (US) | 2010-06-03 | — | — | WO | disclosed |
| US-20070161698-A1 | Modulators of CRTH2 Activity | MICROBIA, INC. | 2007-07-12 | — | — | US | disclosed |
| US-7205329-B2 | Modulators of CRTH2 activity | MICROBIA, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2006099416-A1 | 2-METHYL INDOLE CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2006-09-21 | — | — | WO | disclosed |
| US-20060135591-A1 | Modulators of CRTH2 activity | IRONWOOD PHARMACEUTICALS, INC. | 2006-06-22 | — | — | US | disclosed |
| WO-2006050120-A2 | SYNTHESIS OF COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
| US-20050032747-A1 | COX-2 and FAAH inhibitors | POLYMER CONCEPTS TECHNOLOGIES PBY, INC. | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230524-A1 | SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOLE-3-YL)ACETIC ACIDS AND ETHERS THEREOF AND THE USE OF SAME TO TREAT VIRAL DISEASES | IDO1, TPH1, FOXM1 | PTGS2 3341/4885PTGS1 1860/4885AKR1C3 53/4885 |
| US-20050032747-A1 | COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGS2 | PTGS2 3/4885PTGS1 6/4885AKR1C3 585/4885 |
| US-20060135591-A1 | Modulators of CRTH2 activity | HRH2, HRH1, MRGPRX2 | PTGS2 110/4885PTGS1 189/4885AKR1C3 3064/4885 |
| US-20070161698-A1 | Modulators of CRTH2 Activity | HRH2, HRH1, MRGPRX2 | PTGS2 110/4885PTGS1 189/4885AKR1C3 3064/4885 |
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | PTGS2 4/4885PTGS1 7/4885AKR1C3 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.