⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18136206 | 0.75 | MCHR1 (0.31) | — | |
| SCHEMBL20095974 | 0.73 | — | — | |
| SCHEMBL20095629 | 0.68 | SCN9A (0.33) | — | |
| SCHEMBL19961005 | 0.64 | — | — | |
| SCHEMBL21004272 | 0.63 | PGR (0.36) | — | |
| SCHEMBL18469960 | 0.62 | NOS3 (0.35) | — | |
| SCHEMBL19575420 | 0.60 | SIGMAR1 (0.36) | — | |
| SCHEMBL12049731 | 0.60 | NOS2 (0.47) | — | |
| SCHEMBL18469953 | 0.60 | NCF1 (0.39) | — | |
| SCHEMBL19104241 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115354-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2020-04-16 | — | — | US | disclosed |
| US-10457654-B2 | Therapeutic compounds and methods of use thereof | GENENTECH, INC. (US) | 2019-10-29 | — | — | US | disclosed |
| US-20180105504-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-19 | — | — | US | disclosed |
| US-20180105504-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-19 | — | — | US | disclosed |