Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 18/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 18/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064222 | 0.89 | LMNA (0.45) | LMNAMAPTGAAMAPK1SMN1; SMN2 | |
| SCHEMBL20065594 | 0.83 | ALDH1A1 (0.46) | LMNAMAPTGAAMAPK1SMN1; SMN2 | |
| SCHEMBL21222592 | 0.81 | PDE4D (0.46) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL21222593 | 0.81 | PDE4D (0.46) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL21222109 | 0.78 | LMNA (0.51) | LMNAMAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL20064040 | 0.78 | LMNA (0.51) | LMNAMAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL20064062 | 0.77 | PPARA (0.31) | — | |
| SCHEMBL20064061 | 0.76 | PDE4A (0.35) | MEN1KMT2ACYP3A4 | |
| SCHEMBL20064420 | 0.73 | PPARA (0.57) | LMNAMAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL6897816 | 0.70 | KDM4E (0.49) | LMNAMAPTGAAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |