Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21222642 | 0.80 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DENPP2 | |
| SCHEMBL21222641 | 0.80 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DENPP2 | |
| SCHEMBL20064596 | 0.79 | MEN1 (0.35) | ENPP2ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL20064291 | 0.76 | LMNA (0.43) | CYP3A4MEN1KMT2A | |
| SCHEMBL20064134 | 0.74 | ENPP2 (0.38) | PDE4APDE4BPDE4CPDE4DENPP2 | |
| SCHEMBL21222645 | 0.74 | ENPP2 (0.38) | PDE4APDE4BPDE4CPDE4DENPP2 | |
| SCHEMBL20064420 | 0.74 | PPARA (0.57) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7349242 | 0.73 | ALDH1A1 (0.53) | CYP3A4PTGS1ALDH1A1ALOX5AR | |
| SCHEMBL20064062 | 0.70 | PPARA (0.31) | PPARAKDM4E | |
| SCHEMBL7351472 | 0.70 | DRD2 (0.34) | CYP3A4PTGS1ALDH1A1ALOX5AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069863-A1 | 1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-19 | — | — | WO | disclosed |