Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26419124 | 0.78 | MEN1 (0.59) | ALDH1A1TRPV4MEN1KMT2ANPSR1 | |
| Promolate SCHEMBL1813845 | 0.78 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL20347267 | 0.78 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2ANPSR1EGFR | |
| SCHEMBL11608795 | 0.77 | ALDH1A1 (0.55) | ALDH1A1TRPV4MEN1KMT2ANPSR1 | |
| SCHEMBL20347161 | 0.76 | L3MBTL1 (0.53) | ALDH1A1TRPV4MEN1KMT2ANPSR1 | |
| SCHEMBL874424 | 0.76 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL20350638 | 0.76 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2ANPSR1EGFR | |
| SCHEMBL24838285 | 0.74 | TRPV4 (0.50) | ALDH1A1TRPV4MEN1KMT2ANPSR1 | |
| Oxalic Acid SCHEMBL11606518 | 0.74 | ALDH1A1 (0.51) | ALDH1A1TRPV4MEN1KMT2AEGFR | |
| SCHEMBL12447235 | 0.74 | KMT2A (0.54) | ALDH1A1TRPV4MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105503-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105503-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | ALDH1A1 3597/4885TRPV4 3141/4885MEN1 791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.