Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002063 | 0.92 | ALOX5 (0.33) | PTGES2KDM4EMEN1KMT2ACYP1A2 | |
| SCHEMBL2007450 | 0.90 | LMNA (0.38) | CNR2HDAC6HDAC1HDAC8ALDH1A1 | |
| SCHEMBL2002296 | 0.90 | MAPT (0.33) | PTGES2ALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL2003774 | 0.89 | CNR1 (0.38) | CNR2CNR1HDAC6PTGES2ALDH1A1 | |
| SCHEMBL2009497 | 0.89 | FAAH (0.41) | PTGES2ALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL2002094 | 0.88 | SMN1; SMN2 (0.43) | CNR2HDAC6PTGES2HDAC1HDAC8 | |
| SCHEMBL2004491 | 0.88 | LMNA (0.41) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL2001764 | 0.86 | ALOX5AP (0.39) | CNR2ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL2002147 | 0.86 | ALDH1A1 (0.37) | CNR2CNR1HDAC6PTGES2ALDH1A1 | |
| SCHEMBL2005678 | 0.85 | STAT3 (0.35) | CNR2CNR1PTGES2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |