Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002063 | 0.94 | ALOX5 (0.33) | FAAHMEN1KMT2APTGES2ALOX5 | |
| SCHEMBL2002296 | 0.92 | MAPT (0.33) | FAAHMEN1KMT2AHTTPTGES2 | |
| SCHEMBL2005516 | 0.91 | FAAH (0.33) | FAAHMEN1KMT2ATP53RXFP1 | |
| SCHEMBL2004491 | 0.91 | LMNA (0.41) | FAAHMEN1KMT2AALOX5ALOX5AP | |
| SCHEMBL2004069 | 0.90 | FAAH (0.43) | FAAHMEN1KMT2AHTTPTGES2 | |
| SCHEMBL2001764 | 0.90 | ALOX5AP (0.39) | MEN1KMT2AALOX5ALOX5APMAPT | |
| SCHEMBL2006783 | 0.89 | CNR2 (0.35) | MEN1KMT2APTGES2MAPTCYP1A2 | |
| SCHEMBL2004417 | 0.89 | TP53 (0.44) | FAAHMEN1KMT2AHTTPTGES2 | |
| SCHEMBL2005294 | 0.87 | FAAH (0.41) | FAAHMEN1KMT2AHTTPTGES2 | |
| SCHEMBL4381974 | 0.86 | ALOX5AP (0.38) | ALOX5ALOX5APMAPTCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |