Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006526 | 0.95 | L3MBTL1 (0.39) | LMNAALDH1A1MAPTKDM4EALOX12 | |
| SCHEMBL2004109 | 0.94 | LMNA (0.36) | LMNAALDH1A1MAPTKDM4EALOX12 | |
| SCHEMBL2008957 | 0.94 | LMNA (0.41) | LMNAALDH1A1MAPTKDM4EALOX12 | |
| SCHEMBL2002749 | 0.92 | NPC1 (0.41) | LMNAMAPTKDM4EPKML3MBTL1 | |
| SCHEMBL2002184 | 0.91 | PTGES2 (0.41) | ALDH1A1MAPTKDM4EALOX12HPGD | |
| SCHEMBL2004267 | 0.91 | S1PR1 (0.42) | LMNAMAPTKDM4EPKMMAPK1 | |
| SCHEMBL2009008 | 0.90 | LMNA (0.41) | LMNAALDH1A1MAPTALOX12POLB | |
| SCHEMBL1999738 | 0.89 | CYP2C9 (0.39) | LMNAALDH1A1MAPTALOX12HPGD | |
| SCHEMBL2004314 | 0.89 | RET (0.39) | LMNAALDH1A1MAPTKDM4EALOX12 | |
| SCHEMBL2002145 | 0.85 | LMNA (0.43) | LMNAALDH1A1MAPTKDM4EALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |