Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006916 | 0.94 | LMNA (0.37) | LMNAMAPTALDH1A1KDM4EPKM | |
| SCHEMBL2006526 | 0.91 | L3MBTL1 (0.39) | LMNAMAPTALDH1A1KDM4EPKM | |
| SCHEMBL2004165 | 0.91 | LMNA (0.38) | LMNAMAPTALDH1A1KDM4EALOX12 | |
| SCHEMBL2008957 | 0.90 | LMNA (0.41) | LMNAMAPTALDH1A1KDM4EPKM | |
| SCHEMBL2004301 | 0.90 | RAB9A (0.36) | LMNAMAPTALDH1A1KDM4EALOX12 | |
| SCHEMBL2002558 | 0.90 | RET (0.39) | LMNAMAPTALDH1A1KDM4EPKM | |
| SCHEMBL2002749 | 0.90 | NPC1 (0.41) | LMNAMAPTKDM4EPKMSMN1; SMN2 | |
| SCHEMBL2004267 | 0.89 | S1PR1 (0.42) | LMNAMAPTKDM4EPKMSMN1; SMN2 | |
| SCHEMBL2003553 | 0.87 | GSK3B (0.42) | LMNAMAPTALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL2002184 | 0.86 | PTGES2 (0.41) | MAPTALDH1A1KDM4EALOX12HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |