Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 4/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158489 | 0.86 | RET (0.39) | RETADORA2BCYP46A1NAMPT | |
| SCHEMBL20147392 | 0.85 | OPRM1 (0.39) | RETADORA2BCYP46A1NAMPTSLC6A4 | |
| SCHEMBL20070128 | 0.79 | CCNT1 (0.35) | RETADORA2BCYP46A1NAMPTTACR1 | |
| SCHEMBL20069532 | 0.78 | MAPK1 (0.47) | RETCYP46A1SLC6A4OPRM1OPRD1 | |
| SCHEMBL20137447 | 0.78 | ADORA2B (0.47) | RETADORA2BCYP46A1NAMPTTACR1 | |
| SCHEMBL13231734 | 0.76 | OPRM1 (0.43) | KCNH2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL21651922 | 0.75 | ALDH1A1 (0.48) | CYP46A1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL18713007 | 0.72 | DRD2 (0.49) | — | |
| SCHEMBL21976736 | 0.72 | PKLR (0.40) | RETCYP46A1KCNH2OPRM1OPRD1 | |
| SCHEMBL26514750 | 0.71 | GRIN1 (0.35) | RETADORA2BNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |