Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 3/20 | 0.58 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.58 |
| ▸ | EGFR | P00533 | 6/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CLK3 | P49761 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.40 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147428 | 0.85 | FPR2 (0.53) | FPR2PROKR1ACACBRETIP6K1 | |
| SCHEMBL20158604 | 0.85 | FPR2 (0.53) | FPR2PROKR1ACACBRETIP6K1 | |
| SCHEMBL19172586 | 0.82 | FPR2 (0.42) | FPR2PROKR1SSTR4LRRK2 | |
| SCHEMBL16657599 | 0.79 | FPR2 (0.46) | FPR2PROKR1ACACBIP6K1 | |
| Hydrochloric Acid SCHEMBL29947153 | 0.78 | FPR2 (0.46) | FPR2PROKR1ACACBIP6K1 | |
| SCHEMBL29947210 | 0.78 | GPR119 (0.50) | FPR2PROKR1 | |
| SCHEMBL15536268 | 0.78 | GPR119 (0.50) | FPR2PROKR1 | |
| SCHEMBL20069130 | 0.77 | RET (0.43) | FPR2PROKR1EGFRACACBRET | |
| SCHEMBL19171907 | 0.77 | NOS3 (0.43) | FPR2PROKR1SSTR4LRRK2 | |
| SCHEMBL19941066 | 0.77 | FPR2 (0.63) | FPR2PROKR1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |