Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 3/20 | 0.53 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.53 |
| ▸ | IP6K1 | Q92551 | 4/20 | 0.45 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | SGK1 | O00141 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069587 | 0.85 | FPR2 (0.58) | FPR2PROKR1IP6K1ACACBRET | |
| SCHEMBL20147428 | 0.81 | FPR2 (0.53) | FPR2PROKR1IP6K1ACACBHRH3 | |
| SCHEMBL20205806 | 0.79 | HRH3 (0.45) | HRH3RETWEE1PLK1 | |
| SCHEMBL16657599 | 0.76 | FPR2 (0.46) | FPR2PROKR1IP6K1ACACB | |
| Hydrochloric Acid SCHEMBL29947153 | 0.74 | FPR2 (0.46) | FPR2PROKR1IP6K1ACACB | |
| SCHEMBL15536268 | 0.74 | GPR119 (0.50) | FPR2PROKR1 | |
| SCHEMBL29947210 | 0.74 | GPR119 (0.50) | FPR2PROKR1 | |
| SCHEMBL29947136 | 0.72 | FPR2 (0.45) | FPR2PROKR1IP6K1RETSCD | |
| SCHEMBL18202730 | 0.71 | HRH3 (0.44) | HRH3KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL19941066 | 0.71 | FPR2 (0.63) | FPR2PROKR1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10172845-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180134703-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10172845-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | FPR2 3689/4885PROKR1 438/4885IP6K1 1146/4885 |
| US-20180134703-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | FPR2 3689/4885PROKR1 438/4885IP6K1 1146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.