Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20153172 | 0.87 | ALDH1A1 (0.51) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL22030762 | 0.85 | RET (0.47) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL23126232 | 0.84 | RET (0.49) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL20069825 | 0.84 | KDM4E (0.48) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL22811913 | 0.82 | LMNA (0.51) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL21158715 | 0.82 | ELOVL6 (0.53) | KMT2AMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL20962681 | 0.80 | NNMT (0.46) | MAPTRET | |
| SCHEMBL20206039 | 0.80 | LMNA (0.49) | KMT2AMEN1KDM4EMAPTLMNA | |
| SCHEMBL23555019 | 0.73 | CHRNB2 (0.49) | KMT2AMEN1RET | |
| SCHEMBL23126240 | 0.72 | NNMT (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |