Sugi Predict

Sugi Predict / Compounds / SCHEMBL20073770

SCHEMBL20073770

SCHEMBL20073770

Nc1ccc(C(=O)O)c(C(F)(F)F)n1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABRP O00591 4/20 0.55
▸ GABRD O14764 4/20 0.55
▸ GABRA1 P14867 4/20 0.55
▸ GABRB1 P18505 4/20 0.55
▸ GABRG2 P18507 4/20 0.55
▸ GABRB3 P28472 4/20 0.55
▸ GABRA5 P31644 4/20 0.55
▸ GABRA3 P34903 4/20 0.55
▸ GABRA2 P47869 4/20 0.55
▸ GABRB2 P47870 4/20 0.55
▸ GABRA4 P48169 4/20 0.55
▸ GABRE P78334 4/20 0.55
▸ GABRA6 Q16445 4/20 0.55
▸ GABRG1 Q8N1C3 4/20 0.55
▸ GABRG3 Q99928 4/20 0.55
▸ GABRQ Q9UN88 4/20 0.55
▸ KDM4E B2RXH2 5/20 0.47
▸ ALDH1A1 P00352 3/20 0.47
▸ HPGD P15428 2/20 0.47
▸ HSD17B10 Q99714 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29883463 1.00 GABRP (0.55) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL25193044 0.84 GABRP (0.41) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL1267198 0.81 XPO1 (0.56) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL29724956 0.81 XPO1 (0.56) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL25191608 0.80 PTPN1 (0.41) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6376901 0.79 TAS2R14 (0.45) KDM4EALDH1A1HPGDHSD17B10XPO1
SCHEMBL21645056 0.79 ALDH1A1 (0.41) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6381190 0.78 SORT1 (0.45) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL5355792 0.76 GABRP (0.62) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL20073292 0.76 HPGD (0.44) KDM4EALDH1A1HPGDMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220073527-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2022-03-10 — — US disclosed
US-11220508-B2 TYK2 inhibitors and uses thereof NIMBUS LAKSHMI, INC. (US) 2022-01-11 — — US disclosed
US-11174265-B2 — — 2021-11-16 — — US disclosed
US-20210230163-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-07-29 — — US disclosed
EP-3848370-A2 TYK2 INHIBITORS AND USES THEREOF Nimbus Lakshmi, Inc. (US) 2021-07-14 — — EP disclosed
US-20210094948-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-04-01 — — US disclosed
US-10793574-B2 TYK2 inhibitors and uses thereof NIMBUS LAKSHMI, INC. (US) 2020-10-06 — — US disclosed
US-10647713-B2 TYK2 inhibitors and uses thereof NIMBUS LAKSHMI, INC. (US) 2020-05-12 — — US disclosed
US-20190284194-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-09-19 — — US disclosed
CN-109952303-A TYK2 inhibitor and application thereof 林伯士拉克许米公司 2019-06-28 — — CN disclosed
US-10323036-B2 TYK2 inhibitors and uses thereof NIMBUS LAKSHMI, INC. (US) 2019-06-18 — — US disclosed
US-20180155349-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-06-07 — — US disclosed
US-20180134700-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-05-17 — — US disclosed
WO-2018071794-A1 TYK2 INHIBITORS AND USES THEREOF NIMBUS LAKSHMI, INC. (US) 2018-04-19 — — WO disclosed
CN-104718206-B As insecticide and acaricidal azaindole Methanamide and azaindole thioformamide 拜尔农作物科学股份公司 2017-03-08 — — CN disclosed
CN-104718206-A Azaindole carboxylic acid amides and azaindole thiocarboxylic acid amides for use as insecticides and acaricides BAYER CROPSCIENCE AG 2015-06-17 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11220508-B2 TYK2 inhibitors and uses thereof TYK2, JAK2, JAK1 GABRP 3916/4885GABRD 3421/4885GABRA1 2223/4885
US-20210094948-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK2, JAK1 GABRP 3916/4885GABRD 3421/4885GABRA1 2223/4885
US-10793574-B2 TYK2 inhibitors and uses thereof TYK2, JAK2, JAK1 GABRP 3916/4885GABRD 3421/4885GABRA1 2223/4885
US-10323036-B2 TYK2 inhibitors and uses thereof TYK2, JAK2, JAK1 GABRP 3916/4885GABRD 3421/4885GABRA1 2223/4885
US-20210230163-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK2, JAK1 GABRP 3916/4885GABRD 3421/4885GABRA1 2223/4885
US-20180134700-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK2, JAK1 GABRP 3916/4885GABRD 3421/4885GABRA1 2223/4885
US-20190284194-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK2, JAK1 GABRP 3916/4885GABRD 3421/4885GABRA1 2223/4885
US-11174265-B2 — TYK2, JAK2, JAK1 GABRP 4323/4885GABRD 3976/4885GABRA1 2625/4885
US-20180155349-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK2, JAK1 GABRP 3916/4885GABRD 3421/4885GABRA1 2223/4885
US-10647713-B2 TYK2 inhibitors and uses thereof TYK2, JAK2, JAK1 GABRP 3916/4885GABRD 3421/4885GABRA1 2223/4885
US-20220073527-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK2, JAK1 GABRP 3916/4885GABRD 3421/4885GABRA1 2223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.