Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3683774 | 0.98 | PDE5A (0.36) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL20524316 | 0.79 | HTR2A (0.41) | HTR2AHTR2C | |
| SCHEMBL16416156 | 0.78 | — | — | |
| SCHEMBL28427713 | 0.75 | TDO2 (0.36) | — | |
| SCHEMBL3469250 | 0.74 | MAPK8 (0.30) | — | |
| SCHEMBL21001854 | 0.74 | MAPK8 (0.30) | — | |
| SCHEMBL22234302 | 0.73 | TDO2 (0.35) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL11839119 | 0.73 | ALDH1A1 (0.33) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL11392186 | 0.73 | NUDT1 (0.33) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL11836850 | 0.73 | CHRM4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071526-A1 | HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 2018-04-19 | — | — | WO | disclosed |