Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | CCR9 | P51686 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.34 |
| ▸ | SCD | O00767 | 3/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012375 | 0.94 | FAAH (0.37) | FAAHCCR9PTGES2SCDSCD5 | |
| SCHEMBL2006590 | 0.94 | FAAH (0.40) | FAAHPTGES2SCDSCD5ALOX5 | |
| SCHEMBL2000914 | 0.92 | FAAH (0.42) | FAAHPTGES2SCDSCD5MAPT | |
| SCHEMBL2008885 | 0.92 | LMNA (0.41) | FAAHALOX5ALOX5APMAPTCYP3A4 | |
| SCHEMBL2006267 | 0.91 | FAAH (0.35) | FAAHSCDSCD5MAPTALOX12 | |
| SCHEMBL2009198 | 0.91 | ALOX5AP (0.39) | FAAHALOX5ALOX5APMAPTCYP3A4 | |
| SCHEMBL2005379 | 0.89 | FAAH (0.44) | FAAH | |
| SCHEMBL2004214 | 0.89 | CCR9 (0.37) | FAAHCCR9PTGES2ALOX5ALOX5AP | |
| SCHEMBL2003811 | 0.89 | FAAH (0.41) | FAAHPTGES2SCDSCD5ALOX5 | |
| SCHEMBL2000665 | 0.87 | L3MBTL1 (0.35) | FAAHSCDSCD5MAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |