Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002732 | 0.94 | LMNA (0.33) | PLA2G2APTGS2MAPTALOX5APLMNA | |
| SCHEMBL2005062 | 0.94 | EPHX2 (0.33) | TP53MAPTLMNACYP2C9ALDH1A1 | |
| SCHEMBL2005516 | 0.91 | FAAH (0.33) | PTGDR2TP53LMNACYP2C9MAPK1 | |
| SCHEMBL2004491 | 0.91 | LMNA (0.41) | PLA2G2APTGS2MAPTALOX5APLMNA | |
| SCHEMBL4564522 | 0.91 | NPC1 (0.38) | PLA2G2APTGS2TP53MAPTALOX5AP | |
| SCHEMBL2007750 | 0.91 | L3MBTL1 (0.34) | TP53MAPTLMNAALDH1A1TSHR | |
| SCHEMBL2003124 | 0.91 | PLA2G2A (0.37) | PLA2G2APTGDR2TP53MAPTALOX5AP | |
| SCHEMBL2003311 | 0.90 | PLA2G2A (0.42) | PLA2G2APTGS2PTGDR2MAPTPPARG | |
| SCHEMBL2007930 | 0.90 | PLA2G2A (0.38) | PLA2G2APTGS2TP53MAPTLMNA | |
| SCHEMBL2007450 | 0.89 | LMNA (0.38) | TP53MAPTLMNACYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |