Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005326 | 0.93 | MEN1 (0.43) | MAPTALDH1A1FAAHKDM4ELMNA | |
| SCHEMBL1999528 | 0.92 | ALOX5 (0.37) | MAPTGAAPKMALDH1A1FAAH | |
| SCHEMBL2004090 | 0.91 | PTGES2 (0.40) | MAPTGAAPKMALDH1A1FAAH | |
| SCHEMBL2001701 | 0.90 | MEN1 (0.42) | FAAHMEN1KMT2APTGES2PTGES | |
| SCHEMBL1998892 | 0.89 | ALDH1A1 (0.45) | MAPTALDH1A1FAAHKDM4ELMNA | |
| SCHEMBL2007718 | 0.89 | L3MBTL1 (0.43) | MAPTGAAPKMALDH1A1FAAH | |
| SCHEMBL1999580 | 0.89 | MAPT (0.39) | MAPTGAAPKMALDH1A1FAAH | |
| SCHEMBL1999493 | 0.88 | FAAH (0.43) | FAAHCES1 | |
| SCHEMBL2003596 | 0.88 | PLA2G2A (0.48) | MAPTPKMALDH1A1FAAHLMNA | |
| SCHEMBL2008374 | 0.87 | ALOX5AP (0.44) | ALDH1A1KDM4EKMT2AALOX5APPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |