SCHEMBL20085355

SCHEMBL20085355

CCC(C)c1c(C)cc(Oc2ccccc2F)cc1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.40
ESR1 P03372 1/20 0.40
PARP10 Q53GL7 1/20 0.37
CASP1 P29466 1/20 0.36
CARM1 Q86X55 2/20 0.36
PRMT6 Q96LA8 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
LPAR1 Q92633 3/20 0.36
LPAR5 Q9H1C0 3/20 0.36
LMNA P02545 2/20 0.35
HTT P42858 2/20 0.35
MEN1 O00255 1/20 0.35
GAA P10253 1/20 0.35
KMT2A Q03164 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
HTR2A P28223 1/20 0.35
SLC6A4 P31645 1/20 0.35
MRGPRX1 Q96LB2 2/20 0.35
GCK P35557 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21970592 0.83 CASP1 (0.52) ALDH1A1ESR1PARP10CASP1CARM1
SCHEMBL20085191 0.74 ALDH1A1 (0.46) ALDH1A1ESR1PARP10CASP1LMNA
SCHEMBL20084804 0.73 HTR2A (0.55) ALDH1A1ESR1PARP10LMNAHTT
SCHEMBL18332182 0.72 ALDH1A1 (0.44) ALDH1A1ESR1PARP10LMNAHTT
SCHEMBL20084781 0.71 CASP1 (0.40) PARP10CASP1L3MBTL1LPAR1LPAR5
SCHEMBL18331710 0.71 ALDH1A1 (0.46) ALDH1A1ESR1PARP10CARM1PRMT6
SCHEMBL16792505 0.69 GCK (0.48) ALDH1A1ESR1PARP10L3MBTL1HTT
SCHEMBL30764801 0.69 GCK (0.48) ALDH1A1ESR1PARP10L3MBTL1HTT
SCHEMBL22185245 0.69 CASP1 (0.43) ALDH1A1CASP1GAASMN1; SMN2HTR2A
SCHEMBL18330582 0.69 ALDH1A1 (0.44) ALDH1A1ESR1PARP10CARM1PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3312172-B1 AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS CHUGAI PHARMACEUTICAL CO LTD (JP) 2020-05-06 EP disclosed
EP-3312172-A1 AMINOPYRAZOLE DERIVATIVES Chugai Seiyaku Kabushiki Kaisha (JP) 2018-04-25 EP disclosed