Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15066239 | 0.76 | TAAR1 (0.47) | TAAR1ALDH1A1RIPK1IDO1CXCL8 | |
| SCHEMBL20055723 | 0.72 | TAAR1 (0.34) | TAAR1ALDH1A1RIPK1IDO1LMNA | |
| SCHEMBL21886143 | 0.71 | TAAR1 (0.47) | TAAR1ALDH1A1RIPK1IDO1LMNA | |
| SCHEMBL172686 | 0.70 | TAAR1 (0.45) | TAAR1ALDH1A1RIPK1IDO1LMNA | |
| SCHEMBL13782802 | 0.70 | CES2 (0.36) | ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL435759 | 0.69 | TAAR1 (0.48) | TAAR1ALDH1A1RIPK1IDO1LMNA | |
| SCHEMBL26375984 | 0.68 | TAAR1 (0.40) | TAAR1ALDH1A1IDO1LMNARAB9A | |
| SCHEMBL125583 | 0.66 | ALDH1A1 (0.49) | TAAR1ALDH1A1RIPK1IDO1CXCL8 | |
| SCHEMBL2206253 | 0.65 | ALDH1A1 (0.48) | TAAR1ALDH1A1RIPK1CXCL8LMNA | |
| SCHEMBL29533621 | 0.64 | CXCL8 (0.65) | TAAR1ALDH1A1CXCL8LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312172-B1 | AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-05-06 | — | — | EP | disclosed |
| EP-3312172-A1 | AMINOPYRAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-04-25 | — | — | EP | disclosed |