Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.49 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007853 | 1.00 | APP (0.53) | APPL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL12568180 | 1.00 | APP (0.53) | APPL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL1097898 | 0.87 | ALDH1A1 (0.60) | L3MBTL1ALDH1A1KMT2ACYP3A4MAPK1 | |
| SCHEMBL3085759 | 0.85 | APP (0.67) | APPL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL24303208 | 0.85 | APP (0.67) | APPL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL466232 | 0.83 | APP (0.65) | APPL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL525095 | 0.82 | CYP2D6 (0.56) | L3MBTL1ALDH1A1KMT2ACYP3A4MAPK1 | |
| SCHEMBL4495041 | 0.81 | CYP2D6 (0.52) | L3MBTL1ALDH1A1KMT2ACYP3A4MAPK1 | |
| SCHEMBL25042263 | 0.80 | TAAR1 (0.47) | APPALDH1A1CYP3A4CYP2D6LTA4H | |
| SCHEMBL12568190 | 0.80 | KDM4E (0.49) | APPALDH1A1CYP3A4SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960555-B2 | Substituted pyridine ligands and related water-soluble catalysts | UNIVERSITY OF MASSACHUSETTS (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090156767-A1 | Substituted pyridine ligands and related water-soluble catalysts | NAVY, SECRETARY OF THE UNITED STATES OF AMERICA | 2009-06-18 | — | — | US | disclosed |
| US-20080269444-A1 | PEG-Substituted Pyridine Ligands and Related Water-Soluble Catalysts | EMRICK TODD S | 2008-10-30 | — | — | US | disclosed |
| US-7332609-B2 | PEG-substituted pyridine ligands and related water-soluble catalysts | UNIVERSITY OF MASSACHUSETTS (US) | 2008-02-19 | — | — | US | disclosed |
| US-20060235235-A1 | PEG-substituted pyridine ligands and related water-soluble catalysts | ENERGY, UNITED STATES DEPARTMENT OF | 2006-10-19 | — | — | US | disclosed |
| WO-2006045070-A2 | PEG-SUBSTITUTED PYRIDINE LIGANDS AND RELATED WATER-SOLUBLE CATALYSTS | UNIVERSITY OF MASSACHUSETTS (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156767-A1 | Substituted pyridine ligands and related water-soluble catalysts | MDM4, M6PR, PWWP2B | APP 3640/4885L3MBTL1 3791/4885ALDH1A1 2123/4885 |
| US-20060235235-A1 | PEG-substituted pyridine ligands and related water-soluble catalysts | PAM, EGFR, NAPEPLD | APP 2703/4885L3MBTL1 3562/4885ALDH1A1 2987/4885 |
| US-20080269444-A1 | PEG-Substituted Pyridine Ligands and Related Water-Soluble Catalysts | PAM, EGFR, NAPEPLD | APP 2703/4885L3MBTL1 3562/4885ALDH1A1 2987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.