Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | ICMT | O60725 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GPX4 | P36969 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11138993 | 0.92 | HTR7 (0.51) | HTR7ICMTHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL11139614 | 0.84 | HTR7 (0.56) | HTR7ICMTHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL17084932 | 0.82 | HTR7 (0.48) | HTR7ICMTHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL14612439 | 0.81 | HTR7 (0.45) | HTR7ICMTHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL14287627 | 0.81 | NOS1 (0.52) | HTR7ICMTHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL8095675 | 0.81 | HTR7 (0.47) | HTR7ICMTHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL10980020 | 0.81 | HTR7 (0.47) | HTR7ICMTHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL22537868 | 0.81 | HTR7 (0.47) | HTR7ICMTHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL13475062 | 0.79 | ACHE (0.48) | HTR7ICMTHSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL11317252 | 0.79 | HTR7 (0.52) | HTR7ICMTALDH1A1ACHENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-06-18 | — | — | US | disclosed |
| US-20190105324-A9 | SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2019-04-11 | — | — | US | disclosed |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190105324-A9 | SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKAR2B | HTR7 1816/4885ICMT 4826/4885HSD17B1 1227/4885 |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | HTR7 3479/4885ICMT 4737/4885HSD17B1 3516/4885 |
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | MAP3K1, CSNK1A1, MAP3K2 | HTR7 1836/4885ICMT 4600/4885HSD17B1 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.