Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20096182 | 1.00 | KDM2B (0.42) | KDM2BHRH3L3MBTL3DPP4SLC18A3 | |
| SCHEMBL20095968 | 1.00 | KDM2B (0.42) | KDM2BHRH3L3MBTL3DPP4SLC18A3 | |
| SCHEMBL20096201 | 0.90 | KDM2B (0.38) | KDM2BHRH3L3MBTL3DPP4 | |
| SCHEMBL20096200 | 0.90 | KDM2B (0.38) | KDM2BHRH3L3MBTL3DPP4 | |
| SCHEMBL20096220 | 0.87 | HRH3 (0.44) | KDM2BHRH3L3MBTL3SLC18A3PHGDH | |
| SCHEMBL9048012 | 0.86 | KDM2B (0.41) | KDM2BHRH3L3MBTL3 | |
| SCHEMBL15014587 | 0.80 | KDM2B (0.37) | KDM2BL3MBTL3 | |
| SCHEMBL17285903 | 0.80 | ALDH1A1 (0.41) | KDM2BHRH3L3MBTL3 | |
| SCHEMBL21036749 | 0.80 | L3MBTL3 (0.35) | KDM2BHRH3L3MBTL3 | |
| SCHEMBL23588931 | 0.78 | L3MBTL3 (0.33) | KDM2BL3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |