Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009724 | 1.00 | ALDH1A1 (0.47) | ALDH1A1PKMCASP1CASP8SRC | |
| SCHEMBL2033656 | 0.74 | RIPK1 (0.45) | ALDH1A1PKMDDB1CRBNRIPK1 | |
| SCHEMBL5903467 | 0.70 | CASP1 (0.67) | ALDH1A1PKMCASP1CASP8SRC | |
| SCHEMBL15688484 | 0.69 | NPC1 (0.56) | ALDH1A1PKMKDM4E | |
| SCHEMBL11840921 | 0.69 | ALDH1A1 (0.68) | ALDH1A1PKMCASP1CASP8SRC | |
| SCHEMBL1936056 | 0.68 | ALDH1A1 (0.71) | ALDH1A1PKMKDM4EDDB1CRBN | |
| SCHEMBL1456877 | 0.64 | MEN1 (0.58) | ALDH1A1PKMKDM4ENFKB1NFKB2 | |
| SCHEMBL1456878 | 0.64 | MEN1 (0.58) | ALDH1A1PKMKDM4ENFKB1NFKB2 | |
| SCHEMBL1907404 | 0.64 | MEN1 (0.58) | ALDH1A1PKMKDM4ENFKB1NFKB2 | |
| SCHEMBL10713076 | 0.64 | NAMPT (0.55) | ALDH1A1DDB1CRBNHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507230-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | Syngenta Participations AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011067272-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-09 | — | — | WO | disclosed |