Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 5/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010009 | 0.85 | CA1 (0.45) | CYP1A2CYP2C9CYP2C19HTTCA1 | |
| SCHEMBL6608157 | 0.82 | SMN1; SMN2 (0.44) | CYP1A2CYP2C9CYP2C19HTTCA1 | |
| SCHEMBL6983670 | 0.82 | SMN1; SMN2 (0.44) | CYP1A2CYP2C9CYP2C19HTTCA1 | |
| SCHEMBL6400709 | 0.81 | SYK (0.40) | CYP1A2CYP2C9CYP2C19HTTCA1 | |
| SCHEMBL12301048 | 0.81 | CYP1A2 (0.43) | CYP1A2CYP2C9CYP2C19HTTCA1 | |
| SCHEMBL13651408 | 0.81 | CYP1A2 (0.43) | CYP1A2CYP2C9CYP2C19HTTCA1 | |
| SCHEMBL6400733 | 0.80 | CTSK (0.44) | CYP1A2CYP2C9CYP2C19HTTCA1 | |
| SCHEMBL6605636 | 0.80 | AAK1 (0.49) | CA1CA2CA7CTSKCYP2D6 | |
| SCHEMBL30175074 | 0.80 | CA1 (0.39) | CYP1A2CYP2C9CYP2C19HTTCA1 | |
| SCHEMBL15618538 | 0.78 | CA1 (0.46) | CYP1A2CYP2C9CYP2C19HTTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11357231-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION LLC (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200383330-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2020-12-10 | — | — | US | disclosed |
| US-10750745-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2020-08-25 | — | — | US | disclosed |
| US-20190166842-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2019-06-06 | — | — | US | disclosed |
| US-10206400-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2019-02-19 | — | — | US | disclosed |
| US-20170152250-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2017-06-01 | — | — | US | disclosed |
| US-9609869-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2017-04-04 | — | — | US | disclosed |
| US-20140228577-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2014-08-14 | — | — | US | disclosed |
| US-8735362-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2014-05-27 | — | — | US | disclosed |
| EP-2507230-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | Syngenta Participations AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| US-20120238517-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2012-09-20 | — | — | US | disclosed |
| WO-2011067272-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228577-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | CYP1A2 73/4885CYP2C9 310/4885CYP2C19 1468/4885 |
| US-20200383330-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CYP4X1, NPY4R, CASP3 | CYP1A2 19/4885CYP2C9 88/4885CYP2C19 355/4885 |
| US-20120238517-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | CYP1A2 133/4885CYP2C9 436/4885CYP2C19 1447/4885 |
| US-10206400-B2 | Insecticidal compounds based on isoxazoline derivatives | CHRM1, ACHE, CHRM2 | CYP1A2 73/4885CYP2C9 310/4885CYP2C19 1468/4885 |
| US-11357231-B2 | Insecticidal compounds based on isoxazoline derivatives | CYP4X1, NPY4R, CASP3 | CYP1A2 19/4885CYP2C9 88/4885CYP2C19 355/4885 |
| US-20170152250-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | CYP1A2 73/4885CYP2C9 310/4885CYP2C19 1468/4885 |
| US-10750745-B2 | Insecticidal compounds based on isoxazoline derivatives | CHRM1, ACHE, CHRM2 | CYP1A2 73/4885CYP2C9 310/4885CYP2C19 1468/4885 |
| US-20190166842-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | CYP1A2 73/4885CYP2C9 310/4885CYP2C19 1468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.