Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19033101 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2GAAHPGDNPSR1L3MBTL1 | |
| SCHEMBL26502774 | 0.81 | MEN1 (0.38) | SMN1; SMN2GAAHPGDNPSR1L3MBTL1 | |
| SCHEMBL24938423 | 0.80 | GAA (0.41) | SMN1; SMN2GAAHPGDNPSR1L3MBTL1 | |
| SCHEMBL20234246 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2GAAHPGDNPSR1L3MBTL1 | |
| SCHEMBL20234241 | 0.78 | ALDH1A1 (0.41) | SMN1; SMN2GAAHPGDNPSR1L3MBTL1 | |
| SCHEMBL20104859 | 0.76 | ALDH1A1 (0.42) | SMN1; SMN2GAAHPGDNPSR1L3MBTL1 | |
| SCHEMBL12052384 | 0.76 | TSHR (0.39) | SMN1; SMN2GAAHPGDNPSR1L3MBTL1 | |
| SCHEMBL24242137 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2GAAHPGDNPSR1L3MBTL1 | |
| SCHEMBL24725186 | 0.75 | PLA2G2C (0.40) | SMN1; SMN2L3MBTL1HSD17B10ACACBACACA | |
| SCHEMBL26700232 | 0.74 | PLA2G2C (0.42) | HPGDALDH1A1HSD17B10CES2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118676-A1 | NITRIC OXIDE DONATING DERIVATIVES OF LATANOPROST FREE ACID | NICOX S.A. (FR) | 2018-05-03 | — | — | US | disclosed |
| US-20180118677-A1 | NITRIC OXIDE DONATING DERIVATIVES OF FLUPROSTENOL | NICOX S.A. (FR) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118677-A1 | NITRIC OXIDE DONATING DERIVATIVES OF FLUPROSTENOL | PTGIS, NOS2, PTGIR | SMN1; SMN2 4789/4885GAA 4499/4885HPGD 7/4885 |
| US-20180118676-A1 | NITRIC OXIDE DONATING DERIVATIVES OF LATANOPROST FREE ACID | PTGIS, NOS2, NOS1 | SMN1; SMN2 4557/4885GAA 3479/4885HPGD 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.