Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25516107 | 0.85 | LMNA (0.43) | LMNASMN1; SMN2CYP2D6CYP2C19HPGD | |
| SCHEMBL24379838 | 0.84 | LMNA (0.40) | LMNASMN1; SMN2CYP2D6CYP2C19HPGD | |
| SCHEMBL101552 | 0.83 | HPGD (0.45) | LMNASMN1; SMN2CYP2D6CYP2C19HPGD | |
| SCHEMBL25875336 | 0.83 | LMNA (0.44) | LMNASMN1; SMN2CYP2D6CYP2C19HPGD | |
| SCHEMBL23806315 | 0.82 | LMNA (0.41) | LMNASMN1; SMN2CYP2D6CYP2C19HPGD | |
| SCHEMBL26445199 | 0.81 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2CYP2D6CYP2C19HPGD | |
| SCHEMBL25524815 | 0.81 | LMNA (0.43) | LMNASMN1; SMN2CYP2D6CYP2C19HPGD | |
| SCHEMBL26147450 | 0.81 | LMNA (0.43) | LMNASMN1; SMN2CYP2D6CYP2C19HPGD | |
| SCHEMBL21106880 | 0.81 | LMNA (0.43) | LMNASMN1; SMN2CYP2D6CYP2C19HPGD | |
| SCHEMBL26445198 | 0.81 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2CYP2D6CYP2C19HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118676-A1 | NITRIC OXIDE DONATING DERIVATIVES OF LATANOPROST FREE ACID | NICOX S.A. (FR) | 2018-05-03 | — | — | US | disclosed |
| US-20180118677-A1 | NITRIC OXIDE DONATING DERIVATIVES OF FLUPROSTENOL | NICOX S.A. (FR) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118677-A1 | NITRIC OXIDE DONATING DERIVATIVES OF FLUPROSTENOL | PTGIS, NOS2, PTGIR | LMNA 3760/4885SMN1; SMN2 4789/4885CYP2D6 119/4885 |
| US-20180118676-A1 | NITRIC OXIDE DONATING DERIVATIVES OF LATANOPROST FREE ACID | PTGIS, NOS2, NOS1 | LMNA 2439/4885SMN1; SMN2 4557/4885CYP2D6 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.