Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 2/20 | 0.32 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18058748 | 0.88 | GSK3B (0.39) | GSK3B | |
| SCHEMBL20694863 | 0.88 | GSK3B (0.39) | GSK3B | |
| SCHEMBL20102796 | 0.86 | NR3C2 (0.31) | NR3C2 | |
| SCHEMBL18058838 | 0.79 | MEN1 (0.36) | PIK3CAMAPTKMT2AALDH1A1 | |
| SCHEMBL18058759 | 0.78 | S100A4 (0.34) | MAPTKMT2AALDH1A1 | |
| SCHEMBL18410353 | 0.77 | GSK3B (0.34) | GSK3BMAPTKMT2AALDH1A1 | |
| SCHEMBL17576245 | 0.76 | AKR1C3 (0.44) | GAAMAPTPKMMAPK1KMT2A | |
| SCHEMBL15731795 | 0.75 | PIK3R1 (0.39) | PIK3CAMTORGAAMAPTMAPK1 | |
| SCHEMBL1919863 | 0.74 | AKR1C3 (0.44) | MAPTKMT2AALDH1A1 | |
| SCHEMBL29483984 | 0.74 | RAD51 (0.51) | PRKDCMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590133-B2 | Dimer impurities of Apixaban and method to remove them | F.I.S.-FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2020-03-17 | — | — | US | disclosed |
| US-10385049-B2 | Dimer impurities of apixaban and method to remove them | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2019-08-20 | — | — | US | disclosed |
| US-20180118737-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590133-B2 | Dimer impurities of Apixaban and method to remove them | F2, FGB, F8 | GSK3B 893/4885NR3C2 4402/4885PIK3CA 2209/4885 |
| US-10385049-B2 | Dimer impurities of apixaban and method to remove them | F2, FGB, F8 | GSK3B 893/4885NR3C2 4402/4885PIK3CA 2209/4885 |
| US-20180118737-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F2, FGB, F8 | GSK3B 893/4885NR3C2 4402/4885PIK3CA 2209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.