Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003925 | 0.93 | ALOX5 (0.39) | FAAHMEN1KMT2AALOX5ALOX5AP | |
| SCHEMBL2010143 | 0.92 | PTGES2 (0.42) | FAAHMEN1HTTKMT2AALOX5AP | |
| SCHEMBL2008195 | 0.92 | FAAH (0.36) | FAAHMEN1HTTKMT2AALOX5 | |
| SCHEMBL2007848 | 0.91 | PTGES2 (0.45) | FAAHMEN1HTTKMT2AALOX5 | |
| SCHEMBL2002225 | 0.91 | ALOX5AP (0.39) | ALOX5ALOX5APPTGES2KDM4EMAPT | |
| SCHEMBL2007874 | 0.89 | FAAH (0.41) | FAAHMEN1HTTKMT2AALOX5 | |
| SCHEMBL2001177 | 0.89 | ALOX5AP (0.43) | FAAHMEN1KMT2AALOX5ALOX5AP | |
| SCHEMBL2004831 | 0.89 | PTGES2 (0.38) | MEN1KMT2APTGES2KDM4EALDH1A1 | |
| SCHEMBL2001978 | 0.89 | FAAH (0.45) | FAAHMEN1HTTKMT2AALOX5 | |
| SCHEMBL1997676 | 0.89 | ALOX5AP (0.45) | ALOX5ALOX5APCYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |