Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 3/20 | 0.36 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16015473 | 0.85 | HRH3 (0.40) | LMNATAAR1ALDH1A1ALOX15MEN1 | |
| SCHEMBL20108955 | 0.78 | TLR8 (0.36) | LMNAALDH1A1NOS2TDP1L3MBTL1 | |
| SCHEMBL20109276 | 0.75 | KCNH2 (0.47) | LMNATAAR1ALDH1A1ALOX15MEN1 | |
| SCHEMBL14424238 | 0.74 | SORD (0.31) | — | |
| SCHEMBL20109816 | 0.74 | NOS3 (0.43) | ALDH1A1MEN1KMT2ANOS3NOS1 | |
| SCHEMBL20109474 | 0.74 | MTNR1A (0.39) | ALOX15TDP1 | |
| SCHEMBL20109890 | 0.74 | SORD (0.31) | — | |
| SCHEMBL14234255 | 0.71 | TSHR (0.36) | LMNAMEN1KMT2AHRH3NOS3 | |
| SCHEMBL14233713 | 0.68 | HRH4 (0.33) | HRH3 | |
| SCHEMBL14234022 | 0.67 | KCNH2 (0.41) | LMNANOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534152-B1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-02 | — | — | EP | disclosed |