Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113780 | 0.85 | FGFR4 (0.32) | HTR2AHTR2CHTR2B | |
| SCHEMBL20113958 | 0.77 | FFAR4 (0.33) | NPC1RAB9AKDM4ETSHRTP53 | |
| SCHEMBL20113643 | 0.73 | KDM4E (0.37) | NPC1RAB9AKDM4ETSHRTP53 | |
| SCHEMBL20114332 | 0.71 | NPC1 (0.31) | NPC1RAB9ATSHRNPSR1TP53 | |
| SCHEMBL20113660 | 0.71 | NPC1 (0.31) | NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL20114328 | 0.70 | SRC (0.38) | NPC1RAB9AKDM4ESRCTSHR | |
| SCHEMBL20113778 | 0.67 | NR1I2 (0.32) | NPSR1 | |
| SCHEMBL21503622 | 0.65 | SMN1; SMN2 (0.43) | NPC1RAB9AKDM4ETSHRTP53 | |
| SCHEMBL10299421 | 0.65 | NFKB1 (0.38) | NPC1RAB9AKDM4ETSHRTP53 | |
| SCHEMBL20613016 | 0.64 | POLB (0.32) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |