Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113958 | 0.76 | FFAR4 (0.33) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL20114332 | 0.73 | NPC1 (0.31) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL20113643 | 0.72 | KDM4E (0.37) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL20113656 | 0.71 | HTR2A (0.34) | NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL20113778 | 0.69 | NR1I2 (0.32) | — | |
| SCHEMBL20114328 | 0.69 | SRC (0.38) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL20113780 | 0.64 | FGFR4 (0.32) | — | |
| SCHEMBL10299421 | 0.64 | NFKB1 (0.38) | NPC1TP53PKMRAB9ASMN1; SMN2 | |
| SCHEMBL8497893 | 0.62 | — | — | |
| SCHEMBL20114346 | 0.62 | NPC1 (0.30) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |