Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 6/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113656 | 0.85 | HTR2A (0.34) | HTR2AHTR2CHTR2B | |
| SCHEMBL20113958 | 0.70 | FFAR4 (0.33) | — | |
| SCHEMBL20113643 | 0.66 | KDM4E (0.37) | FGFR4 | |
| SCHEMBL20113709 | 0.66 | FGFR4 (0.36) | FGFR4 | |
| SCHEMBL20114332 | 0.64 | NPC1 (0.31) | — | |
| SCHEMBL20113660 | 0.64 | NPC1 (0.31) | — | |
| SCHEMBL20114328 | 0.63 | SRC (0.38) | FGFR4 | |
| SCHEMBL23104736 | 0.62 | PDE2A (0.39) | PDE1APDE1BPDE1CCNR2 | |
| SCHEMBL20113778 | 0.60 | NR1I2 (0.32) | FGFR4 | |
| SCHEMBL31370997 | 0.59 | PRMT5 (0.38) | FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |