Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PDXK | O00764 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20114328 | 0.83 | SRC (0.38) | KDM4EALDH1A1HPGDMEN1LMNA | |
| SCHEMBL20113958 | 0.78 | FFAR4 (0.33) | KDM4EALDH1A1HPGDMEN1LMNA | |
| SCHEMBL20113656 | 0.73 | HTR2A (0.34) | KDM4ESMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL20113660 | 0.72 | NPC1 (0.31) | SMN1; SMN2NPC1RAB9ATP53PKM | |
| SCHEMBL20113649 | 0.71 | MEN1 (0.37) | KDM4EALDH1A1HPGDMEN1LMNA | |
| SCHEMBL22961170 | 0.68 | NOS3 (0.37) | KDM4EALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL20113872 | 0.68 | NPC1 (0.31) | NPC1RAB9A | |
| SCHEMBL20113778 | 0.68 | NR1I2 (0.32) | FGFR4 | |
| SCHEMBL20113780 | 0.66 | FGFR4 (0.32) | FGFR4 | |
| SCHEMBL10299421 | 0.66 | NFKB1 (0.38) | KDM4EALDH1A1HPGDMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |