Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113958 | 0.75 | FFAR4 (0.33) | KCNJ1 | |
| SCHEMBL13243592 | 0.70 | GABRA1 (0.43) | NPSR1 | |
| SCHEMBL20113660 | 0.69 | NPC1 (0.31) | — | |
| SCHEMBL20113643 | 0.68 | KDM4E (0.37) | FGFR4 | |
| SCHEMBL5527394 | 0.67 | AOC3 (0.44) | NPSR1 | |
| SCHEMBL20113656 | 0.67 | HTR2A (0.34) | NPSR1 | |
| SCHEMBL20114332 | 0.66 | NPC1 (0.31) | NPSR1 | |
| SCHEMBL20114328 | 0.65 | SRC (0.38) | FGFR4 | |
| SCHEMBL10442596 | 0.62 | HCAR2 (0.46) | PIK3CDPIK3CBPIK3CGPIK3C3NPSR1 | |
| SCHEMBL20113780 | 0.60 | FGFR4 (0.32) | FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |