Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 3/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20113958 | 0.66 | FFAR4 (0.33) | KDM4ENPC1RAB9A | |
| SCHEMBL17232467 | 0.66 | MAP4K1 (0.44) | MAP4K1F10MTORPTGS2 | |
| SCHEMBL20113780 | 0.66 | FGFR4 (0.32) | FGFR4 | |
| SCHEMBL20113656 | 0.65 | HTR2A (0.34) | KDM4ENPC1RAB9A | |
| SCHEMBL20113643 | 0.63 | KDM4E (0.37) | FGFR4KDM4ENPC1RAB9A | |
| SCHEMBL15616611 | 0.62 | PTGS2 (0.39) | MAP4K1LRRK2KDM4EF10PIK3CD | |
| SCHEMBL8285966 | 0.61 | PTGS2 (0.45) | MAP4K1F10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL20113660 | 0.61 | NPC1 (0.31) | NPC1RAB9A | |
| SCHEMBL17229320 | 0.61 | ALDH1A1 (0.41) | MAP4K1LRRK2NPC1RAB9AF10 | |
| SCHEMBL7906874 | 0.60 | F10 (0.53) | F10PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3060563-B1 | RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |