Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19345044 | 0.79 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL25361752 | 0.74 | ALDH1A1 (0.42) | ALDH1A1GAAMMP1MMP2MMP3 | |
| SCHEMBL12084310 | 0.73 | MMP1 (0.41) | ALDH1A1GAAMMP1MMP2MMP3 | |
| SCHEMBL6964285 | 0.72 | MGAM (0.31) | GAA | |
| SCHEMBL967474 | 0.71 | ALDH1A1 (0.39) | ALDH1A1GAAMMP1MMP2MMP3 | |
| SCHEMBL968462 | 0.70 | ALDH1A1 (0.42) | ALDH1A1GAAMMP1MMP2MMP3 | |
| SCHEMBL6955652 | 0.69 | — | — | |
| SCHEMBL6955650 | 0.68 | — | — | |
| SCHEMBL23857807 | 0.66 | — | — | |
| SCHEMBL9409043 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273264-B2 | Cortistatin analogues and syntheses and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-04-30 | — | — | US | disclosed |
| US-20180118778-A1 | CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118778-A1 | CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF | CDK9, CDK19, CDK1 | ALDH1A1 3064/4885GAA 3272/4885MMP1 1135/4885 |
| US-10273264-B2 | Cortistatin analogues and syntheses and uses thereof | CDK9, CDK19, CDK1 | ALDH1A1 3064/4885GAA 3272/4885MMP1 1135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.